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Publications 2016/18

Björn U. Christ, Marc I. Combrinck and Kevin G. F. Thomas.  Both Reaction Time and Accuracy Measures of Intraindividual Variability Predict Cognitive Performance in Alzheimer’s Disease.  Frontiers in Human Neurosciences April 2018, Volume 12, Article 124.

John N. Morris, MSW, Anja Declercq , John P. Hirdes , FCAHS ,Harriet Finne-Soveri , Brant E. Fries , Mary L. James ,Leon Geffen, Vahe Kehyayan, Kai Saks, Katarzyna Szczerbi_nska, l, Eva Topinkova.  Hearing the Voice of the Resident in Long-Term Care Facilitiesd An Internationally Based Approach to Assessing Quality of Life.  J Am Med Dir Assoc. 2018 Mar;19(3):207-215. doi: 10.1016/j.jamda.2017.08.010. Epub 2017 Oct 10.

Mahmoud Werfalli, Reshma Kassanjee, Sebastiana Kalula, Paul Kowal, Nancy Phaswana-Mafuya & Naomi S. Levitt.  Diabetes in South African older adults: prevalence and impact on quality of life and functional disability – as assessed using SAGE Wave 1 data.  GLOBAL HEALTH ACTION, 2018 Vol. 11, 1449924.

Sebastiana Z Kalula, Monica Ferreira, George H Swingler, Motasim Badri, Avan A Sayer. Methodological challenges in a study on falls in an older population of Cape Town, South Africa. African Health Sciences, 2017 Vol 17 Issue 3.

Joel Negin, Madeleine Randell, Magdalena Z. Raban, Makandwe Nyirenda, Sebastiana Kalula, Lorna Madurai & Paul Kowa.  Health expenditure and catastrophic spending among older adults living with HIV.  GLOBAL PUBLIC HEALTH, 2017 Vol. 12, No. 10, 1282-1296.

Celeste A. de Jagera, William Msemburib, Katy Pepperc and Marc I. Combrinck.  Dementia Prevalence in a Rural Region of South Africa: A Cross-Sectional Community Study.  Journal of Alzheimer’s Disease 2017;60(3):1087-1096. doi: 10.3233/JAD-170325.

Perianayagam Arokiasamy, Uttamacharya, Paul Kowal, Benjamin D. Capistrant,  Theresa E. Gildner, Elizabeth Thiele, Richard B. Biritwum, Alfred E. Yawson, George Mensah, Tamara Maximova, Fan Wu, Yanfei Guo, Yang Zheng, Sebastiana Zimba Kalula,  Aarón Salinas Rodríguez, Betty Manrique Espinoza, Melissa A. Liebert, Geeta Eick,  Kirstin N. Sterner, Tyler M. Barrett, Kwabena Duedu, Ernest Gonzales, Nawi Ng, Joel Negin, Yong Jiang, Julie Byles, Savathree Lorna Madurai, Nadia Minicuci, J. Josh Snodgrass, Nirmala Naidoo, and Somnath Chatterji. Chronic Noncommunicable Diseases in 6 Low- and Middle-Income Countries: Findings From Wave 1 of the World Health Organization’s Study on Global Ageing and Adult Health (SAGE).  American Journal of Epidemiology 2017 Mar 15;185(6):414-428. doi: 10.1093/aje/kww125

Abuyaman O, Combrinck M, Smith AD, Nexo E. The soluble transcobalamin receptor (sCD320) in relation to Alzheimer's disease and cognitive scores. Scand J Clin Lab Invest. 2017 Sep;77(5):332-337. doi: 10.1080/00365513.2017.1323345. Epub 2017 May 9.

Sebastiana Zimba Kalula, Monica Ferreira, George H. Swingler and Motasim Badri.  Risk factors for falls in older adults in a South African Urban Community. BMC Geriatrics. 2016 Feb 24; 16:51. doi: 10.1186/s12877-016-0212-7

Negin J, Randell M, Raban MZ, Nyirenda M, Kalula S, Madurai L, Kowal P. Health expenditure and catastrophic spending among older adults living with HIV. Glob Public Health. 2016 Apr 30:1-15. [Epub ahead of print]  PMID: 27132656

Biritwum RB, Minicuci N, Yawson AE, Theou O, Mensah GP, Naidoo N, Wu F, Guo Y, Zheng Y, Jiang Y, Maximova T, Kalula S, Arokiasamy P, Salinas-Rodríguez A, Manrique-Espinoza B, Snodgrass JJ, Sterner KN, Eick G, Liebert MA, Schrock J, Afshar S, Thiele E, Vollmer S, Harttgen K, Strulik H, Byles JE, Rockwood K, Mitnitski A, Chatterji S, Kowal P; WHO SAGE Collaboration. Prevalence of and factors associated with frailty and disability in older adults from China, Ghana, India, Mexico, Russia and South Africa.  Maturitas. 2016 Sep;91:8-18. doi: 10.1016/j.maturitas.2016.05.012. Epub 2016 May 24.  PMID: 27451316


Publications  (2010 – 2015)

Peer reviewed publications

Selected research publications of IAA staff members in 2010–2015 are listed below. The titles demonstrate the diversity and particularity of subject areas in which IAA authors engage. IAA authors’ names are shown in bold.

Allie S, Stanley A, Bryer A, Meiring M, Combrinck MI. High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIV-infected patients. International Journal of Stroke 2015; doi:10.1111/ijs.12550. [Epub ahead of print].

Werfalli M, Raubenheimer P, Peer N, Engel M, Kengne AP, Kalula S and  Levitt N. Effectiveness of community-based peer- and  non-professional health worker-led diabetes self-management programs (COMP-DSMP) for improving clinical outcomes and quality of life of adults with  diabetes in primary care settings in low and middle income countries (LMIC): a systematic review protocol. BMJ Open 2015;5:e007635. doi: 10.1136/bmjopen-2015-007635

Kalula SZ, Ferreira M, Swingler GH, Badri M and Sayer AA. Prevalence of falls in an urban community-dwelling older population of Cape Town, South Africa.  (DOI) 10.1007/s12603-015-0528-6 i.  Online publication 29 Apr 2015. http://link.springer.com/article/10.1007/s12603-015-0528-6

Seeburger JL, Holder DJ, Combrinck M, Joachim C, Laterza O, Tanen M, Dallob A, Chappell D, Snyder K, Flynn M, Simon A, Modur V, Potter WZ, Wilcock G, Savage MJ, Smith AD. Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort. J Alzheimers Dis. 2015; 44(2): 525-539.

James KA, Grace LK, Thomas KGF, Combrinck MI. Associations between CAMCOG-R subscale performance and formal education attainment in South African older adults. International Psychogeriatrics 2015; 27(2): 251-260.

Kalula SZ, Ferreira M, Swingler GH, Badri M. Ethnic differences in rates and causes of falls in an urban community-dwelling older population in South Africa. J Am Geriatr Soc. 2015 Feb;63 (2):403-4. doi: 10.1111/jgs.13277.

Khonje V., Milligan C., Yako Y., Mabelane M., Borochowitz K.E., de Jager C.A. Knowledge, attitudes and beliefs about dementia in an urban Xhosa-speaking community in South Africa. Advances in Alzheimer’s Disease, 2015, 4, 21-36 doi.org/10.4236/aad.2015.42004

AD Smith, CA de Jager, H Refsum, IH Rosenberg. Homocysteine lowering, B vitamins, and cognitive aging. The American journal of clinical nutrition, 2015, 101(2), 415-16.

de Jager CA, Joska J, Hoffman M, Combrinck M. Dementia in rural South Africa: a pressing need for epidemiological studies. SAMJ March 2015, Vol. 105, No. 3

Marsico, M. , Jager, C.A. , Grant, A. , Zhu, X. , Markwick, A. and Chandler, J. (2014) Cognitive and Functional Profiles in Mild-to-Moderate Alzheimer’s Disease and Mild Cognitive Impairment Compared to Healthy Elderly. Advances in Alzheimer's Disease, 3, 168-186. doi: 10.4236/aad.2014.34016.

Rentoumi V, Raoufian L, Ahmed S, de Jager CA, Garrard P. Features and machine learning classification of connected speech samples from patients with autopsy proven Alzheimer's disease with and without additional vascular pathology. J Alzheimers Dis. 2014;42 Suppl 3:S3-17. doi: 10.3233/JAD-140555. PubMed PMID:25061045.

de Jager CA, Dye L, de Bruin EA, Butler L, Fletcher J, Lamport DJ, Latulippe ME, Spencer JP, Wesnes K. Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients. Nutr Rev. 2014 Mar;72(3):162-79. Review. PubMed PMID: 24697324.

Barnard ND, Bush AI, Ceccarelli A, Cooper J, de Jager CA, Erickson KI, Fraser G, Kesler S, Levin SM, Lucey B, Morris MC, Squitti R. Dietary and lifestyle guidelines for the prevention of Alzheimer's disease. Neurobiol Aging. 2014 Sep;35 Suppl 2:S74-8. doi: 10.1016/j.neurobiolaging.2014.03.033. Epub 2014 May14. Review. PubMed PMID: 24913896.

de Jager CA. Critical levels of brain atrophy associated with homocysteine and cognitive decline. Neurobiol Aging. 2014 Sep;35 Suppl 2:S35-9. Doi: 10.1016/j.neurobiolaging.2014.03.040. Epub 2014 May 15. Review. PubMed PMID: 24927906.

Ahmed S, Haigh AM, de Jager CA, Garrard P. Connected speech as a marker of  disease progression in autopsy-proven Alzheimer's disease. Brain. 2013 Dec;136(Pt12):3727-37. doi: 10.1093/brain/awt269. Epub 2013 Oct 18. PubMed PMID: 24142144; PubMed Central PMCID: PMC3859216.

Vacante M, Wilcock GK, de Jager CA. Computerized adaptation of The Placing Test for early detection of both mild cognitive impairment and Alzheimer's disease. J Clin Exp Neuropsychol. 2013 Aug 28. [Epub ahead of print].

Trustram Eve C, de Jager CA. Piloting and validation of a novel self-administered online cognitive screening tool in normal older persons: the Cognitive Function Test. Int J Geriatr Psychiatry. 2013 Jun 11. doi: 10.1002/gps.3993. [Epub ahead of print]

Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8. doi:10.1073/pnas.1301816110. Epub 2013 May 20.

Dean K, Oulhaj A, Zamboni G, de Jager CA, Wilcock GK. Role of Depression in Predicting Time to Conversion to Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2013 Apr 20. doi:pii: S1064-7481(12)00135-2. 10.1016/j.jagp.2012.12.025. [Epub ahead of print]

Ahmed S, de Jager CA, Haigh AM, Garrard P. Semantic processing in connected speech at a uniformly early stage of autopsy-confirmed Alzheimer's disease. Neuropsychology. 2013 Jan;27(1):79-85. doi: 10.1037/a0031288.

Rolfson DB, Wilcock G, Mitnitski A, King E, de Jager CA, Rockwood K, Fallah N,Searle SD. An assessment of neurocognitive speed in relation to frailty. Age Ageing. 2013 Mar;42(2):191-6. doi: 10.1093/ageing/afs185. Epub 2013 Jan 7.

Zamboni G, de Jager CA, Drazich E, Douaud G, Jenkinson M, Smith AD, Tracey I, Wilcock GK. Structural and functional bases of visuospatial associative memory in older adults. Neurobiol Aging. 2013 Mar;34(3):961-72. doi:10.1016/j.neurobiolaging.2012.07.011. Epub 2012 Aug 9.

Emmanuel Y, Cochlin LE, Tyler DJ, de Jager CA, David Smith A, Clarke K. Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance. Brain Behav. 2013 Mar;3(2):134-44. doi: 10.1002/brb3.124. Epub 2013 Feb 15.

Hoare J, Westgarth-Taylor J, Fouche JP, Combrinck M, Spottiswoode B, Stein DJ, Joska JA. Relationship between apolipoprotein E4 genotype and white matter integrity in HIV-positive young adults in South Africa. European Archives of Psychiatry and Clinical Neurosciences 2013; 263(3): 189-195.

Cross HM, Combrinck MI, Joska JA. HIV-associated neurocognitive disorders: antiretroviral regimen, central nervous system penetration effectiveness, and cognitive outcomes. South African Medical Journal 2013; 103(10): 758-762.

Langehorne P, de Villiers L, Pandian JD. Applicability of stroke-unit care to low income and middle income countries. Lancet Neurol 2012;11:341-48.

de Villiers L, Badri M, Ferreira M, Bryer A. Stroke outcomes in an economically disadvantaged community. S Afr Med J 2011;101:345-348

Hoare, J., Fouche, J., Spottiswoode, B., Sorsdahl, K., Combrinck, M.I., Stein, D.J., Paul, R.H. and Joska, J. 2011. White-Matter Damage in Clade C HIV-Positive Subjects: A Diffusion Tensor Imaging Study. Journal of Neuropsychiatry and Clinical Neurosciences, 23(3): 308-315.

Joska, J., Westgarth-Taylor, J., Myer, L., Hoare, J., Thomas, K., Combrinck, M.I., Paul, R.H., Stein, D.J. and Flisher, A.J. 2011. Characterization of HIV-associated neurocognitive disorders among individuals starting antiretroviral therapy in South Africa. AIDS and Behavior, 15: 1197-1203.

Kalula, S.Z., Scott, V., Dowd, A. and Brodrick, K. 2011. Falls and falls prevention programmes in developing countries: Environmental scan for the adaption of the Canadian Falls prevention curriculum for developing countries. Journal of Safety Research, 42: 461-472.

Hoare J, Fouche J-P, Spottiswoode B, Sorsdahl, K, Combrinck M, Stein DJ, Paul RH, Joska JH. White Matter Damage in Clade C HIV-Positive Subjects: a Diffusion Tensor Imaging Study. Journal of Neuropsychiatry and Clinical Neuroscience 2011; 23(3): 308-315

Kalula, S.Z., Ferreira, M., Thomas, K., De Villiers, L., Joska, J. and Geffen, L. 2010. Profile and management of patients at a memory clinic. South African Medical Journal, 100(7): 449-451.

Kalula, S.Z., Swingler, G.H., Sayer, A.A., Badri, M. and Ferreira, M. 2010. Does chair type influence outcome in the timed "up and go" test in older persons? Journal of Nutrition Health& Aging, 14(4): 319-323.

Joska, J., Combrinck, M.I., Valcour, V.G., Hoare, J., Leisegang, F., Mahne, A.C., Myer, L. and Stein, D.J. 2010. Association between apolipoprotein E4 genotype and human immunodefiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa. Journal of Neurovirology, 16: 377-383.


Non-peer reviewed publications

de Villiers L and Kalula S Z. An approach to balance problems and falls in elderly persons. South African Medical Journal CME 2015 August; 105(8):1-5

Geffen L. Sexual function and ageing. South African Medical Journal. 2014 15;104(6):450.

Kalula S. Medicine in the elderly: Unique challenges and management. CME – South Africa’s Continuing Medical Education 2013; 31(10):352.

Emeriau JP, Kalula S. Management of hypertension in older persons – specific considerations. CME – South Africa’s Continuing Medical Education 2013; 31(10):358-362.

Kalula SZ. Prevalence and the problem of falls in older persons. Public Health Association of South Africa. May 31, 2012. http://www.phasa.org.za/articles/prevalence-and-the-problem-of-falls-in-older-persons.html

Kalula SZ & George Petros. Responses to dementia in Less Developed Countries with a focus on South Africa. IFA Global Ageing 2011 Vol. 7 No.1: 31-40

Abdool-Gaffar MS, Ambaram A, Ainslie GM, Bolliger CT, Feldman C, Geffen L, Irusen EM, Joubert J, Lalloo UG, Mabaso TT, Nyamande K, O'Brien J, Otto W, Raine R, Richards G, Smith C, Stickells D, Venter A, Visser S, Wong M; COPD Working Group. Guideline for management of chronic obstructive pulmonary disease – 2011 update. S Afr Med J 2011 (1 Pt 2):63-73

de Jager CA Why special steps need to be taken to reduce the risk of dementia in Africa. https://theconversation.com/why-special-steps-need-to-be-taken-to-reduce-the-risk-of-dementia-in-africa-47533

Cape Times, 30 September 2015, page 7. Lisa Isaacs. Africa faces a sharp rise in dementia cases, experts say.

de Jager CA Dementia Prevalence and Impact in Low Income Areas in South Africa. http://www.wun.ac.uk/wun/research/view/dementia-prevalence-and-impact-in-low-income-areas-in-south-africa

Charlton, K. & Kalula, S. (2015). South Africa is failing to address malnutrition in its older people. The Conversation, 24 June 2015 1-3. https://theconversation.com/south-africa-is-failing-to-address-malnutrition-in-its-older-people-43231

Kalula, S.Z. and Ogunniyi, A. 2011. Population Ageing: The Changing Profile of Chronic Diseases in Developing Countries. In N. Phaswana-Mafuya and D. Tassiopoulos (eds), Non-Communicable Diseases (NCDs) in Developing Countries, pp. 179-208. New York: Nova Science Publishers. ISBN 978-1-61209-996-5.

Kalula, S. and Petros, G. 2011. Responses to dementia in Less Developed countries with a focus on South Africa. IFA Global Ageing, 7(1): 31-40.

Celeste A de Jager Marie E Latulippe, Jeremy PE Spencer, and Keith Wesnes. Cognitive function: criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients. Nutrition Reviews. doi:10.1111/nure.12094 Conference abstract


Books/ proceedings

Ahmed S and de Jager CA. Cognitive Assessment: Principles, paradigms & pitfalls. In Nutrition for Brain Health and Cognitive Performance. June, 2015; Editors. CRC press, Taylor and Francis. Cat/ISBN:  K16465 / 9781466570023

de Jager C. A. and Ahmed S. Research on the effects of vitamins and minerals on cognitive function in older adults. In Nutrition for Brain Health and Cognitive Performance. June, 2015; Editors. CRC press, Taylor and Francis. Cat/ISBN:  K16465 / 9781466570023

Hale WA, Joubert JD, Kalula S. Aging population and chronic illness. In Markle WH, Fisher MA, Smego RA (Eds). Understanding global health. New York: McGraw-Hill, 2013: 365-388

Kalula SZ. “Prescribing for the elderly” South African Medicines Formulary. 8th Edition to current 10th Edition (2012).

James, K., Thomas, K., & Combrinck, M. (2011). The Relationship between Traumatic Life Events, High Cortisol and Alzheimer's Disease. ”Re-imagining Psychology: Proceedings of the 2009 Southern African Students' Psychology Conference”.  Editors: Fourie E, Hagen S, Mitchell Y, Semenya B. Consulting Editor: Terre Blanche M Publisher: University of South Africa. ISBN 978-0-620-50471

Kalula S, Khalil D, Perold A, Ross KJB, De Villiers L and Van Niekerk S. Nursing care for the older person. A Practical Approach. Heinmann Publishers ISBN: 9780796224828 2011

Ross KJB Normal ageing. In Nursing care for the older person. Heinmann Publishers ISBN: 9780796224828 2011: 1-21

de Villiers L. Assessment of functioning in the elderly. In Nursing care for the older person. Heinmann Publishers ISBN: 9780796224828 2011: 47-72

Ross KJB. Geriatric syndrome: Incontinence. In Nursing care for the older person. Heinmann Publishers ISBN: 9780796224828 2011: 77-98

de Villiers L Geriatric syndromes: The frailty syndrome and immobility. In Nursing care for the older person. Heinmann Publishers ISBN: 9780796224828 2011:99-111

Kalula SZ. Instability and falls in older persons. In Nursing care for the older person.  Heinmann Publishers ISBN: 9780796224828 2011: 113-125

Ross KJB. Geriatric syndrome: the confused patient. In Nursing care for the older person. Heinmann Publishers ISBN: 9780796224828 2011: 149-170

Kalula SZ. Drugs and the older person. In Nursing care for the older person

Heinemann Publishers. ISBN: 9780796224828. 2011: 171-182

Kalula SZ, Ogunniyi A. Population ageing and the changing profile of chronic disease in developing countries. In Phaswana-Mafuya N, Tassiopoulos D (Eds). Non Communicable Diseases (NCDs) in developing countries. New York: Nova Science Publishers USA. 2011: 179-208

de Jager C. 2010. Memory in the Elderly. In: JH Stone, M Blouin, editors. International Encyclopedia of Rehabilitation. Available online: http://cirrie.buffalo.edu/encyclopedia/article.



de Jager CA. Vitamin D and Cognition: Are There Any Cautions Against Intervention Trials for Older Adults. [Editorial] Vitamins & Minerals, 2014, 3:2

de Jager CA (2013) Why Don’t We Know What to Eat in the 21st Century? A Focus on Coronary Heart Disease and Dementia Prevention. Vitam Trace Elem 2: e120. doi:10.4172/2167-0390.1000e120